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Dan Luo, Zhengyun Zuo, Hongyan Zhao, Yong Tan, Cheng Xiao
《医学前沿(英文)》 2019年 第13卷 第5期 页码 556-563 doi: 10.1007/s11684-018-0649-5
关键词: Tripterygium wilfordii Hook F immunoregulation clinical studies
麻醉与意识的脑网络研究进展——框架与临床应用 Review
刘军, 董康立, 孙毅, Ioannis Kakkos, 黄帆, 王国正, 齐鹏, 陈星, 张德林, Anastasios Bezerianos, 孙煜
《工程(英文)》 2023年 第20卷 第1期 页码 77-95 doi: 10.1016/j.eng.2021.11.013
尽管麻醉与意识之间的关系一直是研究者关注的重点,但目前学界对于麻醉与意识的神经机制理解仍处在初级阶段,极大地限制了麻醉监测和意识评估系统的进一步发展。此外,现有麻醉监测方法难以提供足够的有效信息,对精准麻醉监测的目标构成了障碍。近年来,使用脑网络分析揭示麻醉机制已成为研究热点,其目的是为临床应用提供新的研究思路。针对这一新的研究趋势,本文全面回顾了麻醉相关脑网络研究的最新进展,系统地比较了麻醉和意识的几种潜在的神经机制以及不同层面大脑神经活动的测量方法;从皮层碎片化理论出发,介绍了连通性和网络分析的一些重要的研究方法和相关成果;在总结归纳现有研究成果的基础上,论证了全脑多模态网络数据可以提供现有麻醉监测方法所无法提供的信息;更重要的是,进一步探讨简化脑网络分析方法的可行性,这一方法将会在优化现有的临床麻醉监测系统中发挥重要作用。
Genome-wide association studies: inherent limitations and future challenges
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《医学前沿(英文)》 2012年 第6卷 第4期 页码 444-450 doi: 10.1007/s11684-012-0225-3
Genome-wide association studies (GWAS) have achieved great success in identifying genetic variants related to complex human diseases such as cancer and have provided valuable insights into their genetic architecture. Recently, GWAS is quite the fashion in China. However, there are issues related to its nature. Enormous work needs to be done in the post-GWAS era. Deep sequencing followed by functional studies will be needed to elucidate the underpinning biological mechanisms and further translate GWAS findings into medical practice. Along with pharmacogenomics, the success of GWAS in identifying genetic risk factors and genetic differences in drug response has been gradually enabling personalized medicine. In this article, we used hepatocellular carcinoma (HCC) as an example to demonstrate some of the inherent limitations and summarized future challenges of GWAS.
关键词: genome-wide association studies (GWAS) genetic variant cancer limitation challenge
Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia
null
《医学前沿(英文)》 2015年 第9卷 第1期 页码 1-9 doi: 10.1007/s11684-015-0381-3
With the cure rate of childhood acute lymphoblastic leukemia (ALL) approaching 90%, further improvement in the treatment outcome and quality of life of patients will require better understanding of the mechanisms of drug resistance, identifying new leukemic cell genetic lesions that are amendable to available target therapy, and optimizing treatment based on host pharmacodynamics and pharmacogenomics. Deeper characterization of leukemic cell genetic abnormalities has discovered new subtypes of leukemia such as early T-cell precursor ALL and Philadelphia chromosome-like ALL, and identified many genomic alterations that have diagnostic, prognostic, or therapeutic implications. In this regard, several novel fusion transcripts are responsive to ABL tyrosine kinase inhibitors and potentially to JAK inhibitors. Genome-wide analyses have also unraveled the role of inherited cancer predisposing genes and small nucleotide polymorphisms of several genes in the development of childhood ALL. These advances promise to lead to more sophisticated personalized treatment strategies in the near future.
关键词: pharmacogenomics acute lymphoblastic leukemia genomics pharmacogenetics
《环境科学与工程前沿(英文)》 2023年 第17卷 第8期 doi: 10.1007/s11783-023-1694-0
● Data quality assessment criteria for MP/NPs in food products were developed.
关键词: Microplastic Nanoplastic Food products Data quality Human health risk
何华武
《中国工程科学》 2009年 第11卷 第5期 页码 23-30
高速道岔是高速铁路轨道结构的关键,其结构与状态对列车运行安全和运行品质具有重大影响。文章介绍了高速道岔设计参数和平面线形,扣件、岔枕、道岔转换系统等部件主要结构特征,高速道岔设计理论,相关技术条件及取得的创新成果,对于中国高速铁路道岔的进一步研制、试验验证及推广使用具有重要的指导意义。
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
《农业科学与工程前沿(英文)》 2022年 第9卷 第1期 doi: 10.15302/J-FASE- 2021390
It has previously been shown that tryptophan, the biosynthesis precursor of Peganum harmala alkaloids, and its derivatives have anti-TMV activity both in vitro and in vivo. Further exploration of this led to the identification of NK0238 as a highly effective agent for the prevention and control of diseases caused by plant viruses, but the existing routes are unsuitable for its large-scale synthesis. This study optimized a route for two-step synthesis of this virucide candidate via reaction of l-tryptophan with triphosgene to produce l-tryptophan-N-carboxylic anhydride, which then reacts with n-octylamine to give NK0238 at up to 94% yield and nearly 97% HPLC purity. In addition, the route was used for the preparation of NK0238 on a>40 g scale permitting further assessment of its antivirus activity in the greenhouse and field experiments, and toxicity tests. NK0238 exhibited useful antiviral activities against a variety of viruses both in greenhouse and field experiments. The toxicity tests showed that NK0238 was not acutely toxic to birds, fish, honey bees and silkworms. The optimized route provides a solid foundation for its large-scale synthesis and subsequent efficacy and toxicity studies, its excellent activity and safety make NK0238 a promising drug candidate for further development.
Jianxian ZENG, Junfeng LIU, Niandong HUANG,
《化学科学与工程前沿(英文)》 2010年 第4卷 第3期 页码 360-366 doi: 10.1007/s11705-009-0269-3
Ontological reconstruction of the clinical terminology of traditional Chinese medicine
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《医学前沿(英文)》 2014年 第8卷 第3期 页码 358-361 doi: 10.1007/s11684-014-0348-9
This study proposes the ontological reconstruction of the current clinical terminology of traditional Chinese medicine (TCM). It also provides an overview of preliminary work related to the said reconstruction, including the ontology-based analysis of TCM clinical terminology. We conclude that the ontological reconstruction of TCM clinical terminology provides a proper translation from the idealized organizational model to real-world implementation and to a formalized, shared, and knowledge-based framework.
关键词: ontology traditional Chinese medicine clinical terminology
Parameter studies on impact in a lap joint
Amir M. RAHMANI,Elizabeth K. ERVIN
《机械工程前沿(英文)》 2015年 第10卷 第1期 页码 64-77 doi: 10.1007/s11465-014-0322-x
To represent a loose lap joint, a beam impacting four springs with gaps is modeled. Modal analysis with base excitation is solved, and time histories of contact points are closely monitored. Using the impulse during steady state response, six influential parameters are studied: damping ratio, contact stiffness, intermediate contact position, gap, excitation amplitude and beam height. For all parameters, the system response is highly controlled by modes with two contacting springs. Each parameter’s effect on system response is presented including unstable regions, unique trend behaviours result. Recommendations for structural designers are also noted.
关键词: impact mechanics contact joint behaviour modal analysis parameter study
Simulation studies on metastable phase equilibria in the aqueous ternary systems (NaCl-MgCl
Tianlong DENG, Baojun ZHANG, Dongchan LI, Yafei GUO
《化学科学与工程前沿(英文)》 2009年 第3卷 第2期 页码 172-175 doi: 10.1007/s11705-009-0048-1
关键词: green chemistry solar pond technique simulation metastable phase equilibrium solubility
《医学前沿(英文)》 2023年 第17卷 第3期 页码 527-533 doi: 10.1007/s11684-022-0967-5
关键词: orthotopic heart transplant tricuspid regurgitation clinical impact biatrial heart transplantation
Experimental studies on the influence of porosity on membrane absorption process
GAO Jian, REN Zhongqi, ZHANG Zeting, ZHANG Weidong
《化学科学与工程前沿(英文)》 2007年 第1卷 第4期 页码 385-389 doi: 10.1007/s11705-007-0070-0
Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment
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《医学前沿(英文)》 2017年 第11卷 第3期 页码 340-348 doi: 10.1007/s11684-017-0570-3
In light of the rapid increase in the number of obesity incidences worldwide, obesity has become an independent risk factor for chronic kidney disease. Obesity-related glomerulopathy (ORG) is characterized by glomerulomegaly in the presence or absence of focal and segmental glomerulosclerosis lesions. IgM and complement 3 (C3) nonspecifically deposit in lesions without immune-complex-type deposits during ORG immunofluorescence. ORG-associated glomerulomegaly and focal and segmental glomerulosclerosis can superimpose on other renal pathologies. The mechanisms under ORG are complex, especially hemodynamic changes, inflammation, oxidative stress, apoptosis, and reduced functioning nephrons. These mechanisms synergize with obesity to induce end-stage renal disease. A slow increase of subnephrotic proteinuria (<3.5 g/d) is the most common clinical manifestation of ORG. Several treatment methods for ORG have been developed. Of these methods, renin–angiotensin–aldosterone system blockade and weight loss are proven effective. Targeting mitochondria may offer a novel strategy for ORG therapy. Nevertheless, more research is needed to further understand ORG.
关键词: obesity-related glomerulopathy pathogenesis pathologic clinical characteristics
Coronavirus disease 2019 (COVID-19): a clinical update
Min Zhou, Xinxin Zhang, Jieming Qu
《医学前沿(英文)》 2020年 第14卷 第2期 页码 126-135 doi: 10.1007/s11684-020-0767-8
关键词: coronavirus disease 2019 epidemiology pathology radiology clinical characteristics treatment
标题 作者 时间 类型 操作
麻醉与意识的脑网络研究进展——框架与临床应用
刘军, 董康立, 孙毅, Ioannis Kakkos, 黄帆, 王国正, 齐鹏, 陈星, 张德林, Anastasios Bezerianos, 孙煜
期刊论文
Data quality assessment for studies investigating microplastics and nanoplastics in food products: Are
期刊论文
ROUTE DEVELOPMENT, ANTIVIRAL STUDIES, FIELD EVALUATION AND TOXICITY OF AN ANTIVIRAL PLANT PROTECTANT
期刊论文
Experimental studies on extraction of cobalt ions from dilute aqueous solutions by using complexation-ultrafiltration
Jianxian ZENG, Junfeng LIU, Niandong HUANG,
期刊论文
Simulation studies on metastable phase equilibria in the aqueous ternary systems (NaCl-MgCl
Tianlong DENG, Baojun ZHANG, Dongchan LI, Yafei GUO
期刊论文
The clinical impact of tricuspid regurgitation in patients with a biatrial orthotopic heart transplant
期刊论文
Experimental studies on the influence of porosity on membrane absorption process
GAO Jian, REN Zhongqi, ZHANG Zeting, ZHANG Weidong
期刊论文
Obesity-related glomerulopathy: pathogenesis, pathologic, clinical characteristics and treatment
null
期刊论文